Most "energy" supplements only work if you're actually deficient. We explain what iron, B vitamins, vitamin D and caffeine tablets can and can't do.

Fatigue is one of the most common reasons Australians see their GP, and it has a long list of causes that no supplement will fix. Iron deficiency and anaemia, an underactive thyroid (hypothyroidism), obstructive sleep apnoea, depression, anxiety, diabetes, coeliac disease and side effects from medications can all leave you exhausted. These are picked up with a conversation, an examination and often a simple blood test — not by guessing at the pharmacy.
This matters because self-supplementing can delay a real diagnosis. If you spend three months taking an 'energy' multivitamin while an undiagnosed thyroid problem or sleep disorder goes untreated, you have lost time and money. See your GP if tiredness lasts more than two weeks, is getting worse, or comes with other symptoms such as breathlessness, unexplained weight change, heavy periods, low mood, or feeling unrefreshed after a full night's sleep.
Iron deficiency is one of the genuine, well-established nutritional causes of fatigue. Iron is needed to make haemoglobin, the protein in red blood cells that carries oxygen around your body. When iron stores run low, tissues get less oxygen and you feel tired, weak, and short of breath. In this specific situation, correcting the deficiency can make a real difference to how you feel.
The catch is that iron only helps if you are actually low. Low iron and low ferritin (your iron stores) are common in menstruating women, pregnant women, vegetarians and vegans, regular blood donors and endurance athletes — but they are not universal. A blood test measuring ferritin and a full blood count is the only way to know. Do not diagnose yourself: taking iron supplements you do not need can cause gut side effects and, in the wrong person, harmful iron overload. If a test confirms deficiency, your GP or pharmacist can recommend an appropriate oral iron product and dose.
B vitamins (including B12, folate, B6 and thiamine) are marketed relentlessly as 'energy' vitamins because they help your cells release energy from food. That biochemistry is real, but it does not mean extra B vitamins add energy when you already have enough. If your diet and blood levels are normal, a B-complex supplement will not make you feel more energetic — your body simply excretes the surplus.
Deficiency is a different story. Vitamin B12 deficiency causes genuine fatigue and is more common in vegans and vegetarians (B12 comes almost entirely from animal foods), older adults, and people on long-term metformin or acid-suppressing medications. Correcting a confirmed B12 or folate deficiency can restore energy. Again, the honest position is: get tested if deficiency is suspected, rather than assuming a high-dose 'energy' B supplement is doing anything if your levels are already fine.
Vitamin D deficiency is common in Australia despite the sunny reputation, particularly in people who cover up for cultural or sun-safety reasons, those with darker skin, older adults, and anyone who spends most of the day indoors. Low vitamin D is associated with tiredness, muscle weakness and low mood, and correcting a confirmed deficiency may help some people feel better.
That said, vitamin D is not a reliable 'energy' fix if your levels are already adequate, and the evidence for supplementing well-nourished people to improve fatigue is weak. If you suspect you are low, a GP can order a blood test and advise on an appropriate dose. Taking very high doses without testing is not recommended, as excess vitamin D can cause harm over time.
Caffeine tablets (such as No-Doz and pharmacy equivalents) contain a measured dose of caffeine, typically around 100mg per tablet — roughly the caffeine in a strong cup of coffee. They can genuinely increase short-term alertness and reduce the feeling of drowsiness, which is why some people reach for them during a long drive or a demanding shift. What they do not do is treat the underlying reason you are tired.
Using caffeine to paper over chronic fatigue has real downsides. Tolerance builds, so you need more for the same effect. Caffeine taken later in the day disrupts sleep, which deepens the tiredness you were trying to fix — a vicious cycle. Higher doses can cause anxiety, jitteriness, a racing heart and stomach upset. Healthy adults are generally advised to stay under about 400mg of caffeine a day from all sources, and it is easy to overshoot if you combine tablets with coffee, tea, cola and energy drinks. People who are pregnant or breastfeeding, or who have heart conditions, high blood pressure or anxiety, should check with a pharmacist or GP before using caffeine tablets.
This table cuts through the marketing. The common thread is that most of these only do something if you are genuinely deficient — which is exactly why a blood test matters more than the label.
| Supplement | Helps energy only if... | Evidence | Caution |
|---|---|---|---|
| Iron | A blood test confirms low iron / ferritin | Strong (for confirmed deficiency) | Don't take without testing — excess iron is harmful; can cause constipation and nausea |
| Vitamin B12 | You are deficient (vegans, older adults, some medications) | Strong (for confirmed deficiency) | No benefit if your levels are already normal |
| B-complex ('energy' vitamins) | You have an underlying B-vitamin deficiency | Weak in well-nourished people | Surplus is simply excreted; won't add energy |
| Vitamin D | A blood test confirms you are low | Moderate for deficiency; weak otherwise | Very high doses without testing can cause harm |
| Caffeine tablets | You need short-term alertness (not a chronic fix) | Effective for temporary alertness only | Tolerance, sleep disruption, anxiety; keep total caffeine under ~400mg/day |
| Multivitamin / 'energy' formulas | You have a specific dietary gap | Weak for fatigue in healthy adults | Marketing outpaces evidence; check for a real deficiency first |
For most tired people without a medical cause, the biggest improvements come from unglamorous basics rather than supplements. These cost nothing and address the actual drivers of everyday fatigue.
The supplement aisle is full of products promising to 'boost energy', 'fight fatigue' or 'revitalise'. In Australia, these are typically listed complementary medicines (with an AUST L number), which means the TGA has assessed them for safety and quality but not proven that they work for the claims on the front of the pack. The phrase 'supports energy production' usually just refers to the fact that a nutrient plays a role in normal metabolism — not that the product will make a well-nourished person feel more energetic.
A useful rule of thumb: if a supplement's benefit depends on you being deficient, the honest first step is to find out whether you actually are. Be especially wary of pricey 'adrenal support', 'metabolism' or proprietary 'energy blends' that stack many ingredients at token doses. The most evidence-based money you can spend on your energy is often the cost of a GP visit and a blood test.
Only the ones that correct a genuine deficiency. If a blood test shows you are low in iron, vitamin B12 or vitamin D, replacing that nutrient can meaningfully improve energy. If your levels are normal, no supplement reliably increases energy in a healthy person. That is why testing beats guessing — and why persistent tiredness is worth a GP visit rather than a trial-and-error tour of the supplement aisle.
Not without a blood test first. Iron only helps fatigue if you are actually iron deficient, which is common in menstruating women, pregnant women and vegetarians but far from universal. Taking iron you do not need can cause constipation and nausea, and excess iron can build up and cause harm. Ask your GP for a ferritin and full blood count test; if it confirms you are low, they can recommend an appropriate iron product and dose.
Only if you were deficient to begin with. B vitamins help your cells release energy from food, which is why they are marketed as 'energy' vitamins, but taking extra when your levels are already normal does not add energy — your body just excretes the surplus. Vitamin B12 deficiency (more common in vegans, older adults and some people on long-term medications) can cause real fatigue, and correcting a confirmed deficiency helps. Otherwise, a B-complex is unlikely to do much.
Used occasionally by healthy adults, caffeine tablets are generally safe and can improve short-term alertness — one tablet is roughly a strong coffee's worth of caffeine. They are not a fix for chronic fatigue, though, and regular use brings tolerance, disrupted sleep, anxiety and a racing heart. Keep your total caffeine from all sources under about 400mg a day. People who are pregnant or breastfeeding, or who have heart problems, high blood pressure or anxiety, should speak to a pharmacist or GP first.
Feeling unrefreshed despite a full night's sleep is a classic reason to see your GP rather than self-supplement. Common explanations include obstructive sleep apnoea (where breathing is interrupted overnight), iron deficiency, an underactive thyroid, depression, diabetes and certain medications. A GP can sort through these with a few questions and a blood test. Guessing with 'energy' supplements risks delaying the diagnosis of something straightforward to treat.
There is little evidence that 'energy' multivitamins reduce fatigue in people who eat a reasonable diet. They may help if you have a specific dietary gap, but for most people the claims are marketing rather than proven benefit. In Australia these are listed medicines assessed for safety and quality, not for whether they deliver the energy boost on the label. If you are persistently tired, a blood test to check for a real deficiency is a better investment than a broad-spectrum 'energy' formula.
This information is general in nature and isn’t a substitute for professional medical advice. Always read the label and follow the directions for use. Talk to your pharmacist or doctor about what’s right for you.

Tired, pale or breathless? Learn the signs of low iron, why a blood test must come first, and how to compare and take Australian iron supplements correctly.

Nearly 1 in 4 Australians has low vitamin D. Learn the symptoms, what your nmol/L result means, how much sun you need, and which supplements may help.

Glycinate, citrate, oxide or threonate? An Australian guide to magnesium benefits, the best form for sleep, cramps and stress, plus dosing and cautions.